SYRE
Spyre Therapeutics Inc.NASDAQ
Healthcare • Biotechnology
Updated 1 day ago
Coverage limited
$80.45-6.34%
Close Oct 13, 2026
- Market cap
- —
- 1 month
- -11.4%
- 3 months
- -21.2%
- 1 year
- +320.3%
- 52-week range
- $21.00$108.92
- Dividend
- No dividends on record
- Next-quarter EPS estimate
- -$0.83Quarter to Sep 30, 2026 · 13 analysts · revenue $0
- Short interest
- 15.6% of float12.8M shares · settled Sep 30, 2026 · +5.9% since Sep 15, 2026 · FINRA
Fundamentals · trailing 12 months to Jun 30, 2026
- Revenue
- $90.49M
- Net income
- -$178.92M
- Free cash flow
- -$208.94M
- Book value
- $1.1B
- Total debt
- —
- P/E
- —
- Price / sales
- —
- Price / book
- —
- FCF yield
- —
- Net margin
- -197.7%
EODHD (TTM) · as of Oct 13, 2026
End-of-day close from stored market data, not a live quote.
Portfolio context
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Loading market dates
No upcoming ex-dividend date announced
No 8-K filings in the last 30 days.
Smart money context
Holder IQ: MEDIUM
60 top institutions tracked
as of 2026-Q2 (filed 2026-09-23)
Last 13F trend: distributing (light)
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Sentiment: bearish
Last trade: sell 13 days ago
Red flags: 0
Largest 13-F holders · Q2 2026
267 filers reported a long position in SYRE for Q2 2026. 13-F holdings are filed up to 45 days after the quarter ends.
| Holder | Value | Shares | Shares vs Q1 2026 |
|---|---|---|---|
| FMR LLC | $1.2B | 13M | +10.6% |
| BlackRock, Inc. | $577.7M | 6.5M | +17.8% |
| PERCEPTIVE ADVISORS LLC | $383.5M | 4.3M | +14.2% |
| RTW INVESTMENTS, LP | $377.5M | 4.3M | +1.9% |
| Paradigm Biocapital Advisors LP | $341M | 3.8M | +96.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | $306.2M | 3.4M | +12.8% |
| STATE STREET CORP | $271.4M | 3.1M | +17.3% |
| Venrock Adviser, LLC | $265M | 3M | -19% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $262.9M | 3M | +85.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | $248.5M | 2.8M | +0.3% |
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